Prevention of Episodic Migraine Headache

A 37-year-old woman presents with recurrent headaches. The headaches occur once or twice a week. She describes them as very painful, pounding, and always on one side of the head, accompanied by sensitivity to light and sound. She is otherwise healthy and uses only ibuprofen, which provides partial relief. She has never tried other abortive medications. The headaches last 5–7 hours, improve in a dark room, and have occurred about twice a week for several years, significantly affecting her quality of life. Physical examination shows no neurological deficits or other abnormalities. You diagnose her with episodic migrane, you discuss treatment options with her. She is interested in preventive therapy.

Volume 41.2 - Question 39

Gepants and Migraine

Which one of the following statements regarding calcitonin gene-related peptide receptor antagonists (gepants) in the treatment of acute migraine is false?

  • They inhibit neuroinflammation and vasodilation associated with migraine development.
  • They have demonstrated superiority compared to placebo for improved function at 2 hours.
  • There are no vascular contraindications.
  • They have been approved for treatment in children.
Volume 40.6 - Question 21

Triptans and Migraines

Which one of the following statements about triptans for the acute treatment of migraines is false?

  • There is no evidence for difference in treatment outcomes between various triptans.
  • Nearly one-third of patients using triptans will have inadequate response.
  • They are approved for use in children younger than six.
  • They should be avoided in patients with a history of myocardial infarction.
Volume 40.6 - Question 20

Migraine Headache Prophylaxis

Candesartan is effective for prevention of episodic and chronic migraines.

  • True
  • False
Volume 40.5 - Question 21

Acute Management of Migraine

The best performing triptans (eletriptan, rizatriptan, sumatriptan, and zolmitriptan) should be considered as preferred acute treatment for migraine.

  • True
  • False
Volume 40.4 - Question 25

Migraine Treatments

Which one of the following statements regarding the treatment of migraine is false?

  • Taking NSAIDs on an empty stomach may increase effectiveness.
  • There is a high risk of serotonin syndrome when combining a triptan and a selective serotonin reuptake inhibitor (SSRI).
  • Prokinetic medications such as metoclopramide can boost the effectiveness of analgesic medications.
  • Subcutaneous administration is more effective than oral administration of triptans.
Volume 40.2 - Question 13

Migraine

Which one of the following statements about migraine is false? 

  •  Aura symptoms may occur in the absence of a subsequent headache.   
  • There is good evidence to support dietary approaches for the treatment of migraine in adults.   
  • If one oral triptan is ineffective, others in the drug class may provide adequate pain relief.   
  • Topiramate has been shown to be effective for chronic migraine. 
Volume 36.3 - Question 24

Migraine

A 40 year-old female presents to your office with complaints of episodic headaches that are not responding to over-the counter ibuprofen. Headaches are accompanied by nausea and photophobia, and have caused her to miss work. She would like you to prescribe an antibiotic, as she feels these are sinus headaches, having been diagnosed with this previously when she presented to an after-hours clinic.  However, you suspect a diagnosis of migraine, but there are several mimics that should be considered in the diagnosis first. 

Volume 37.4 - Question 43

Migraine

A 30-year-old patient presents to your office. She has had migraines since adolescence. Today she asks you how to manage the headaches and what you know about the new treatments for migraine.

Volume 38.5 - Question 42

Pharmacologic Prevention of Migraine

Which one of the following statements about migraine prevention is false?

  • Migraine prophylaxis should be offered to patients with 4 or more migraine headache days per month.
  • Preventative treatment should be considered for patients with atypical aura.
  • OnabotulinumtoxinA (Botox) injection has shown a reduction in headache days by 50% or more.
  • Calcitonin gene-related peptide monoclonal antibodies take 6 months to show statistically significant treatment effect.
Volume 38.5 - Question 13

Essential Thrombocythemia

Which one of the following statements about essential thrombocythemia is false?

  • Most cases of severe thrombocytosis are secondary to essential thrombocythemia.
  • The presence of cardiovascular risk factors substantially increases the risk of thrombosis.
  • Aspirin is often effective for pain in the hands and feet.
  • Patients with essential thrombocythemia who develop venous thrombosis are treated similarly to individuals with venous thrombosis without essential thrombocythemia.
Volume 40.6 - Question 31

Opioids for Headache

Opioid prescriptions for headache in the emergency department are associated with higher rates of long-term prescription opioid use.

  • True
  • False
Volume 40.5 - Question 11

Epilepsy

Your next patient is a 19-year-old female. While cooking supper, her girlfriend witnessed the patient lose consciousness and experience a tonic-clonic generalized seizure. The ambulance brought the patient to the emergency room.  

Volume 40.21 - Question 2

Placebo Injections for Back Pain

A single nondeceptive placebo injection for chronic back pain reduces pain intensity more than usual care.

  • True
  • False
Volume 40.1 - Question 24

Sport-related Concussion

You are seeing a 24-year-old competitive baseball player. This afternoon, as he attempted to steal second base, he was struck in the head by a player’s knee. Although he was wearing a protective helmet, he immediately developed headache, dizziness and nausea. He does not remember the details of the accident this afternoon. You suspect a sport-related concussion (SRC).

Volume 35.61 - Question 30

Epilepsy

Your next patient is a 19-year-old female. While cooking supper, her girlfriend witnessed the patient lose consciousness and experience a tonic-clonic generalized seizure. The ambulance brought the patient to the emergency room.  

Volume 39.4 - Question 44

Cluster Headache

Which one of the following statements about cluster headache is false?

  • Photophobia is a typical symptom.
  • It is associated with one or more ipsilateral autonomic symptoms including conjunctival injection and lacrimation.
  • It can last from 15 to 180 minutes.
  • Neuroimaging with computed tomography or magnetic resonance imaging is not routinely recommended.
Volume 37.3 - Question 24

Postural Orthostatic Tachycardia Syndrome

Which one of the following statements about POTS (postural orthostatic tachycardia syndrome) is false?

  • Orthostatic hypotension precludes the diagnosis of POTS.
  • Most patients with POTS have low cardiac stroke volume.
  • Numerous cases of POTS after SARS-CoV-2 infection have been reported.
  • A tilt table test is required for diagnosis.
Volume 37.6 - Question 27

Peripheral Nerve Blocks for Primary Headaches

Peripheral nerve blocks are effective as a rapid treatment option for the treatment of primary headache disorders, which include migraine, tension headache, and cluster headaches.

  • True
  • False
Volume 37.6 - Question 18

HPV Vaccine

Human papillomavirus vaccination is associated with an increased risk of Guillain-Barre syndrome. 

  • True
  • False
Volume 36.4 - Question 3

Oral NSAIDs

Which one of the following statements about oral NSAIDs is false?

  • They are less effective for functional improvement compared to acetaminophen.
  • They may be considered for short-term treatment of acute pain related to fractures when the risk of bleeding is not significant.
  • They increase the risk of cardiovascular events by about 30%.
  • They may cause acute kidney injury as a result of reduced renal blood flow.
Volume 37.1 - Question 10

Coronary-artery Dissection

Which one of the following statements about spontaneous coronary-artery dissection (SCAD) is false? 

  • It occurs primarily in women between 47 and 53 years of age.  
  • Up to 50% present with STEMI.  
  • Approximately one quarter of initial troponin levels are normal.  
  • Thrombolysis is recommended for acute SCAD.
Volume 36.3 - Question 2

Haloperidol in Headache

Haloperidol (2.5 mg intravenously) is a rapid and effective treatment for acute, severe, benign headache in ED patients aged 18 to 55 years. 

  • True
  • False
Volume 36.2 - Question 27

Transient Global Amnesia Recurrence Risk

Which one of the following factors is not associated with an increased risk of recurrence of transient global amnesia? 

  •  Earlier age at time of first episode 
  • Personal history of migraine 
  •  Family history of migraine 
  •  Characteristic electroencephalographic findings
Volume 36.1 - Question 27

Haloperidol in Headache

Haloperidol (2.5 mg intravenously) is a rapid and effective treatment for acute, severe, benign headache in emergency department patients aged 18 to 55 years. 

  • True
  • False
Volume 36.1 - Question 21

Contraception

You are working today at a Community Public Health Clinic and seeing various patients with different contraceptive concerns. Your first patient, an 18 year-old female, is at your office today because she is interested in emergency contraception. She had unprotected intercourse last night.  

Volume 38.1 - Question 38

Temporomandibular Disorders

Which one of the following is not recommended in the treatment of temporomandibular disorders?

  • Opioids
  • Cyclobenzaprine
  • Amitriptyline
  • Gabapentin
Volume 38.4 - Question 24

Venous Thromboembolism with Use of Hormonal Contraception

In women using high or medium risk hormonal contraception, concomitant use of NSAIDs for 1 week is associated with an increase in the risk of venous thromboembolic events.   

  • True
  • False
Volume 39.1 - Question 3

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