Diagnosis and Treatment of Hypertension

You are a community family physician heading into a meet and greet appointment with your new patient, a 56-year-old male. His vital signs are: BP 155/97 mm Hg, heart rate 84 bpm and regular, weight 95 kg and height 175 cm. Calculated BMI is 31 kg/m2. He states his past medical history is benign. He endorses smoking 10 cigarettes per day and consumes 2 beers per day.

Volume 41.2 - Question 40

Orthostatic Hypertension

More intensive blood pressure treatment modestly reduces the occurrence of orthostatic hypertension.

  • True
  • False
Volume 40.6 - Question 26

Risk of Hypertension after Kidney Donation

Normotensive living kidney donors have a higher risk of hypertension than normotensive non-donors in the first 7 years following donation.

  • True
  • False
Volume 40.1 - Question 37

Treatment of Hypertension

Hydrochlorothiazide has a lower risk of causing hypokalemia than indapamide.  

  • True
  • False
Volume 39.5 - Question 30

Hypertension

For those with office systolic blood pressures of 130-139mm Hg and diastolic blood pressures of 85-89mm Hg, more than half will develop hypertension within four years.  

  • True
  • False
Volume 36.4 - Question 28

Low dose Quad-pill for Hypertension Versus Standard Dose Monotherapy

Hypertension treatment with a fixed dose quadruple agent (irbesartan, amlodipine, indapamide and bisoprolol) can achieve greater blood pressure lowering as compared to antihypertensive monotherapy at standard doses.

  • True
  • False
Volume 37.1 - Question 28

Pulmonary Arterial Hypertension

Which one of the following statements about pulmonary arterial hypertension is false?

  • Diagnosis is delayed in many cases as symptoms are nonspecific.  
  • Murmur of tricuspid regurgitation is suggestive.
  • Right heart catheterization is not required for diagnosis.
  • Atrial septostomy is a treatment option in some cases.
Volume 37.4 - Question 21

Treatment of Chronic Hypertension in Pregnancy

 Which one of the following statements about antihypertensive treatment for pregnant women with chronic hypertension is false? 

  • Amlodipine is associated with a lower rates of preeclampsia.  
  • Atenolol is associated with a higher risk of small-for-gestational-age infants.   
  • Nifedipine is associated with a lower incidence of severe hypertension. 
  • Methyldopa is associated with lower rates of placental abruption.
Volume 36.1 - Question 3

Hypertension in Pregnancy

In pregnant women with mild chronic hypertension, active treatment with a blood-pressure target of less than 140/90 mm Hg was associated with better pregnancy outcomes than a strategy of no antihypertensive treatment unless the systolic blood pressure was 160 mm Hg or higher or the diastolic pressure was 105 mm Hg or higher.

  • True
  • False
Volume 38.2 - Question 3

Treatment for Mild Chronic Hypertension during Pregnancy

In pregnant women with mild chronic hypertension, a strategy of targeting a blood pressure of <140/90 is associated with better pregnancy outcomes than reserving treatment only for severe hypertension.

  • True
  • False
Volume 37.5 - Question 7

Hypertension in Hospitalized Elderly Patients

Intensive inpatient treatment of asymptomatic hypertension in older adults admitted for non-cardiac conditions is associated with better outcomes.

  • True
  • False
Volume 39.2 - Question 12

Leptomeningeal Disease

Which one of the following statements about leptomeningeal disease is false?

  • Autopsy studies suggest that it may often go undetected.
  • Prognosis has historically been very poor with no treatment.
  • Non-hematological cancers are associated with a better prognosis than hematologic cancers.
  • Patients may present with signs of cauda equina syndrome.
Volume 41.1 - Question 37

Metabolic Dysfunction-Associated Steatotic Liver Disease

Which one of the following statements about metabolic dysfunction-associated steatotic liver disease (MASLD) is false?

  • Weight loss of at least 10% is needed to reduce liver fibrosis.
  • Semaglutide has been shown to exert hepatoprotective effects.
  • SGLT2 inhibitors do not have hepatoprotective effects.
  • No liver-directed pharmacotherapies are available for the treatment of MASLD-related cirrhosis.
Volume 41.1 - Question 32

Sudbury Clinical Decision Rule for Vertigo

The Sudbury vertigo risk score can identify the risk for a serious diagnosis in patients presenting with vertigo.

  • True
  • False
Volume 41.1 - Question 20

Trigeminal Neuralgia

A 55-year-old female patient is at your office today complaining of recurrent episodes of left facial pain in the trigeminal nerve area over the past month. Her pain lasts up to 2 minutes and is severe in intensity. She describes the pain as electrical shock-like, shooting, stabbing, and sharp in quality. You have diagnosed her as likely having trigeminal neuralgia.

Volume 40.6 - Question 35

Accidental Cannabis Ingestion

Which one of the following statements about accidental cannabis ingestion in young children is false?

  • Many edible products contain multiple doses of tetrahydrocannabinol (THC).
  • Patients with severe toxicity experience symptoms for more than 6 hours.
  • Hypertension is the main blood pressure abnormality in patients with marijuana toxicity.
  • Symptoms of severe toxicity include seizures.
Volume 40.6 - Question 33

Essential Thrombocythemia

Which one of the following statements about essential thrombocythemia is false?

  • Most cases of severe thrombocytosis are secondary to essential thrombocythemia.
  • The presence of cardiovascular risk factors substantially increases the risk of thrombosis.
  • Aspirin is often effective for pain in the hands and feet.
  • Patients with essential thrombocythemia who develop venous thrombosis are treated similarly to individuals with venous thrombosis without essential thrombocythemia.
Volume 40.6 - Question 31

Atrial Fibrillation

In patients with AF and stable CAD, oral anticoagulation monotherapy, when compared with oral anticoagulation plus single antiplatelet therapy, is associated with a statistically significant increased risk of ischemic events.        

  • True
  • False
Volume 40.6 - Question 29

Kounis Syndrome

Which one of the following statements about Kounis Syndrome (KS) (allergic angina) is false?

  • It is diagnosed in 2% of patients with anaphylaxis.
  • Common findings in Type I KS include normal cardiac enzymes.
  • Beta blockers are a recommended treatment.
  • Epinephrine should be reserved for cases involving airway compromise, refractory shock, or hypotension.
Volume 40.6 - Question 25

Blood Pressure in a Noisy Setting

Automated blood pressure readings in a noisy public space yield similar results to those obtained in a quiet office setting.

  • True
  • False
Volume 40.6 - Question 22

Steatotic Liver Disease in the Office

Phosphatidylethanol is a biomarker which may identify moderate or heavy alcohol consumption in the past 3 to 4 weeks.

  • True
  • False
Volume 40.5 - Question 29

Significance of Coronary Calcium Seen on Lung Cancer Screening

Among people undergoing a low-dose chest CT for lung cancer screening, an incidental finding of extensive coronary artery calcium is an independent predictor of all-cause death and cardiovascular events.

  • True
  • False
Volume 40.4 - Question 28

Diagnosis of Perimenopause

An elevated follicle-stimulating hormone (FSH) level is required in order to make the diagnosis of perimenopause.

  • True
  • False
Volume 40.4 - Question 12

Venous Insufficiency

Which one of the following statements about chronic venous insufficiency is false?

  • Venous insufficiency increases the risk of venous thrombotic events.
  • Swelling of the dorsum of the foot indicates lymphatic dysfunction.
  • Duplex ultrasound evaluation can discern venous hypertension.
  • When necessary, thiazides and mineralocorticoid antagonist diuretics are preferred over loop diuretics.
Volume 40.3 - Question 34

Aortic Stenosis

Which one of the following statements about calcific aortic stenosis is false?

  • Auscultation of a cardiac murmur has a sensitivity less than 50 %.
  • Hypertension is associated with a 2-fold higher rate of valve calcification.
  • Direct oral anticoagulant medications are contraindicated in patients with mechanical heart valves.
  • Antibiotic prophylaxis is not recommended for routine dental cleanings in patients with a prosthetic valve.
Volume 40.3 - Question 33

Endometrial Thickening

Postmenopausal women without bleeding or risk factors do not require further investigations if they are found to have endometrial thickness < 11 mm on ultrasound.

  • True
  • False
Volume 40.3 - Question 14

Sudden Vision Loss

Which one of the following statements about the management of sudden vision loss is false?

  • Because intravenous thrombolysis may be beneficial in selected patients with central artery occlusion within the first 4.5 hours, emergent consultation with a stroke neurologist is recommended in the hyperacute period.
  • Following embolic central retinal artery occlusion, underlying modifiable systemic risk factors should be addressed because the patient is at high risk of a cerebrovascular event or a similar incident in the second eye.
  • When there is high clinical suspicion for giant cell arteritis, empiric steroids should be delayed until a temporal artery biopsy is obtained.
  • High-dose corticosteroids are the first-line treatment for acute optic neuritis because they shorten visual recovery time compared with placebo.
Volume 40.3 - Question 1

Obesity Management

Your next patient is a 38-year-old woman. After several years of struggling with obesity, she wishes to address this issue. The patient is healthy, with no known medical conditions.   You question your patient about her eating habits and physical activity. She has a very healthy lifestyle. You complete a physical examination. In addition to measuring the patient’s body-mass index, you also measure the patient’s waist circumference.

Volume 40.21 - Question 13

Osteoporosis Guidelines

One of your patients comes to see you in the office for a renewal of her hypertension medications. While there, she asks if she should have a bone mineral density test as many of her friends have started getting them.  

Volume 40.21 - Question 4

Midodrine for Vasovagal Syncope

Midodrine is a reasonable treatment option for adults with recurrent vasovagal syncope without a history of hypertension, heart failure, or urinary retention.

  • True
  • False
Volume 40.2 - Question 31

Unstable Bradycardia and Transcutaneous Pacing

In the prehospital setting, the incidence of true electrical capture in patients receiving transcutaneous pacing is less than 20%.

  • True
  • False
Volume 40.2 - Question 16

Prenatal Cannabis Use and Maternal Pregnancy Outcomes

Prenatal cannabis use is associated with a greater risk of all the following except:

  • Excessive gestational weight gain
  • Gestational diabetes
  • Preeclampsia
  • Placental abruption
Volume 40.2 - Question 7

Extreme Heat and Health

Which one of the following statements regarding climate change, extreme heat and health is false?

  • The relative risk of death from myocardial infarction is increased on heat wave days.
  • The risk of suicide is increased with the 93rd percentile warm season temperature compared with the 1st percentile.
  • A 1 degree C increase in temperature is associated with an increase in the risk of stillbirth.
  • Heat action plans have not been shown to reduce deaths per hot day.
Volume 40.2 - Question 5

Renal Cancer Update

A 65-year-old woman presents with gross hematuria and no other symptoms. She is found on ultrasound to have a small renal mass.

Volume 40.1 - Question 40

Management of Insomnia

Which one of the following statements about the management of insomnia is false?

  • Mindfulness-based therapy has more data to support its efficacy than cognitive behavioural therapy for insomnia (CBT-I).
  • Melatonin has been shown to have a small effect on sleep onset in adults.
  • Complex behaviours during sleep, such as driving, are a patient-reported side effect of benzodiazepine receptor agonists.
  • CBT-I used alone produces more sustained benefits than when used in combination with medication.
Volume 40.1 - Question 28

Hypertensive Disorders of Pregnancy

The rate of severe maternal morbidity associated with hypertensive disorders of pregnancy has decreased in Canada between 2012 and 2021.

  • True
  • False
Volume 40.1 - Question 14

Heart Failure with Preserved Ejection Fraction

Which one of the following statements about heart failure with preserved ejection fraction (HFpEF) is false?

  • Approximately 20% of patients with HFpEF have normal natriuretic peptide levels.
  • It is associated with low socioeconomic status.
  • HFpEF comprises a larger percentage of heart failure in men than in women.
  • SGLT2 inhibitors are an effective treatment.
Volume 39.6 - Question 36

Thiazide Induced Hyponatremia

Thiazide-induced hyponatremia is more common in the initial month of treatment compared to one year later.

  • True
  • False
Volume 39.6 - Question 31

Energy and Macronutrients Across the Life Span

Which one of the following statements on energy and macronutrients across the life span is false?

  • Suboptimal diets contribute to one in five deaths worldwide.
  • Reducing intake of sodium to the level of <2300 mg a day is associated with a decreased risk of hypertension.
  • Plant proteins are usually deficient in one more indispensable amino acids.
  • Cholesterol is an essential dietary lipid.
Volume 39.6 - Question 7

Low Dose Colchicine

Among patients with type 2 diabetes and a recent myocardial infarction, colchicine 0.5 mg daily reduces the relative risk of further major cardiovascular events by more than 25%.

  • True
  • False
Volume 39.6 - Question 1

Urinary Incontinence in Adults

Diarrhea is associated with an increased risk of urge urinary incontinence in adults. 

  • True
  • False
Volume 39.5 - Question 38

Prevention of Cardiovascular Disease in Type 1 Diabetes

Which one of the following statements about prevention of cardiovascular disease in type 1 diabetes is false?   

  • Levels of glycated hemoglobin are closely correlated with the risk of adverse cardiovascular outcomes.   
  • Statin use is consistently recommended.   
  • GLP-1 receptor agonists have not been specifically studied in patients with type 1 diabetes.   
  • Persons with type 1 diabetes are at greater risk of cardiovascular disease than the general population. 
Volume 39.5 - Question 37

Polycystic Ovarian Syndrome

Which one of the following statements about polycystic ovary syndrome (PCOS) is false? 

  • Androgen levels cannot be measured reliably while a patient is on combined hormonal contraceptives.   
  • The addition of metformin to combined hormonal contraceptives can be considered in patients with PCOS in high metabolic risk groups.   
  • The risk of endometrial cancer is 2–6 times higher among people with PCOS than the general population and often presents before menopause. 
  • With assisted reproduction, the cumulative probability of childbirth is lower in patients with PCOS than those without.
Volume 39.5 - Question 10

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